呋喃西林是一種(zhǒng)硝基呋喃類門到抗菌藥物，曾被(bèi)廣泛應用于水産養殖過(guò)程中。呋喃西林在動物白司體内的代謝物氨基脲（SEM）會(huì)與細胞膜蛋商門白緊密結合，形成(chéng)結合态殘留物紙廠，穩定而長(cháng)期存在于動物體内，具有緻科微癌、緻畸性。本文簡要介紹了呋喃西林藥物的藥理作用及有友其應用，綜述了兩(liǎng)種(zhǒng村黑)應用于SEM檢測的主要方法——高效液相色譜（HP家子LC）及其聯用技術和免疫分析法的研究進(jì著弟n)展情況及其優缺點，以及食品術房中的SEM來源，以期對(duì)呋喃西林藥物及其代謝物SEM有一個較爲見匠完整的了解，也爲進(jìn)一步開(筆生kāi)展相關研究奠定理論基礎。

Research Progress 錯城on Nitrofurazone and Its 我海Metabolite ofSemicarbazide in Animal-de畫暗rived Food

Nitrofurazone，as anitrofuran antibioti近內c，had been widely used inaquaculture.不船 However，the sem國都icarbazide（SEM），a kind of metabolite樂船 generated bynitrofurazone錢著 within animal's body，could 器什closelyincorporate wit我近h cell membrane protein to form bound雨北 residues which wou事那ldexisted in animal's b匠機ody for a long time wi說木th carcinogenicity andteratogenicity. I老會n this paper，the pharma草話cologicaleffects and application 著鄉of nitrofurazone were briefl年嗎y introduced. Besides，the research prog那暗ress，advantages and著林disadvantages of the ma黃她in methods for SEM d門綠etection，includinghigh perf機快ormance liquid chromatogr了雨aphy（HPLC）and its c輛外ombined technology and im女短munoassay were summariz視呢ed，the sources of SEM in food w麗笑as also summarized，hoping生就 to comprehensively recog鄉店nize the nitrofurazone and 體空itsmetabolite of s白科emicarbazide，and to國章 provide theoretic都玩alfoundation for 跳你further research.時但