新型冠狀病毒（2019-nCoV）感染肺炎疫情自冷技2019年12月在湖北省武漢市發(fā)生以來，已在我國(guó)和村樹世界多個國(guó)家傳播，引發(fā)全球關美拿注。爲闡明2019-nCoV與已知動物冠狀病毒的關系，從冠狀病毒的宿我長主分布、遺傳進(jìn)化分析、宿主受體店近分析等角度，對(duì)2019-nCo金煙V的可能(néng)來源進(jìn)行了綜合分析。結果顯示：2019影西-nCoV與從雲南省中菊頭蝠中檢哥生測到的冠狀病毒分離株RaTG13基因組相地同源性最高，爲96.2%，兩(liǎ了著ng)者遺傳進(jìn)化關系也較爲接近；從我國(guó音年)廣東省和廣西壯族自治區查獲的動從走私穿山甲中檢測到的冠狀病毒則與2019話大-nCoV遺傳關系相對(duì)稍遠，與2019-nCoV基因組去秒同源性分别爲90.4%和85.5%跳可；2019-nCoV與已知家畜、家禽，以是低及犬貓等寵物中檢測到的冠狀病毒基因組同源性≤54.2%，遺傳書技進(jìn)化關系較遠。結合監測結果，基本排除2019-nCoV來源于已知家自空畜、家禽以及犬貓等寵物冠狀病毒的可能(說歌néng)性。
Phylogenetic Analysis between花拍 the Novel Coronavir車朋us（2019-nCoV）and&nbs音快p;Animal Coronavi湖爸ruses
Since the outbreak of友黃 pneumonia caused by the novel c草拿oronavirus（2019-nCoV）in Wuhan Cit筆懂y of Hubei Prov門舞ince in December 2019，it可友 has spread in China and many other 短慢countries around t大銀he world，which is t舞些he focus of global attention.見這 In order to clarify the re看音lationship between 2019-nCoV and the得事 known animal coronaviruses，the c間大omprehensive analysis was performed t年市o find the possible so路可urce of 2019-nCoV based on the host 朋畫distribution，genetic phylogeneti站開c analysis，host海少 receptor analysis of coron了雜aviruses in the study. The results 這弟showed that the genome homo業鐵logy between 2019-nCoV and外是 the coronavirus RaTG13 detected 也舊from Rhinolophus affinis in Yunan Pro舊車vince was the highes唱身t（96.2%），and 2019-n讀市CoV was closely related to 水哥RaTG13 in genetic phylogen電藍etic analysis. The geneti呢弟c relationship between 2019-nCoV 什討and the two coronavir答可uses detected f山睡rom seized smugg動通ling pangolin in Guan醫討gdong and Guangx放器i were relatively longer compare分分d with RaTG13，a算喝nd the genome homology of the 201說黑9-nCoV with coro制土naviruses detected from seized s坐哥muggling pangolin in Guang吧關dong and Guangxi was 90可很.4% and 85.5%，respectiv學林ely. Genetic dis又爸tance between 20舞校19-nCoV and coronaviruses o日紙btained from known 海見domestic livesto河長ck，poultry，pets including do綠老gs and cats was genetically long，and 草市the genome homol少讀ogy of 2019-nCoV with them 歌也was≤54.2%. Combined with the河鄉 published surveillance results，視舊the possibility of 20唱線19-ncov originating from the know金在n coronaviruses of domestic 冷劇livestock，poultry，pe妹文ts including dogs 人問and cats is basically excluded.
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