布魯氏菌病的早期診斷及鑒定是該病防控身不的重要環節，其診斷技術主要包括細菌學(xué)診斷技術、血清學(xué)診斷技廠件術以及分子生物學(xué)診斷技術。布魯氏菌病防控應堅持預防爲道工主的策略，其免疫主要以弱毒活疫苗爲主，随著(zhe)分子生好兵物學(xué)及重組DNA技術的發(fā)展，基因工程疫苗成(chéng)海黑爲近年研究熱點，但目前尚未有鑒别疫苗免疫和自黃少然感染的鑒别診斷技術及相應的疫苗制品。本文對(duì)布魯氏菌病的病原學要金(xué)、流行病學(xué)、診斷技術和疫苗研究進(jìn)展愛窗等方面(miàn)進(jìn)行分電概述，以期爲建立靈敏性高、特異性強、高效便捷舊內且易推廣的布魯氏菌病診斷技術和研發(fā)更加安全有效的布魯氏菌病疫苗提車知供基礎。

Research Progress on Brucellosis

It is the key to prevent and contro秒多l brucellosis by 人開early diagnosis and城習 identification th秒月at mainly include的中 the technologie事間s of bacteriology，serology店熱 and molecular biology. 制船The brucellosis va高市ccines have been play她花ing an important role due to the st錯影rategy of“Preve窗哥ntion First”，and the live attenuated跳朋 vaccines are commonly used 呢關at present. With the development o哥慢f molecular biology and recombina個區nt DNA technology，genetic engi日明neering vaccine has d老船eveloped rapidly and b請呢ecome a hotspot in recent years. Howe唱可ver，no any differenti村舊al diagnosis technologies a數來nd corresponding vaccine products for d著廠istinguishing vaccine小長 immunity from natur船上al infection have been availabl快我e. In this paper，the eti請自ology，epidemiology，diagnosis technolog姐到y and brucellosis va慢說ccine development s很拿tatus were summarized，兵是which laid a foundation for the est為亮ablishment of a po玩年pularized diagnosis technology with hi還很gh sensitivity，specificity市鄉 and efficiency，as well as紙件 for the development of the 街放more effective and s明們afer vaccines.

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