布魯氏菌病（簡稱布病）是一種(zhǒng)由黑區布魯氏菌引起(qǐ)的嚴重危害人中唱和動物健康的人獸共患病。疫苗免疫是畜間布病流行率較的刀高地區控制該病的重要手段。遼甯省建昌縣經(jīng)過店黃(guò)多年實踐，創新出一套免鐵媽疫保護效果較好(hǎo)的陰道(dào)途徑免疫S2疫苗的新型家畜免疫訊樹技術。爲了解該技術對(duì)家畜的安全性，本研男頻究采用該技術免疫了3隻山羊，在免疫1個月後(hòu)檢測其抗體滴度湖內、體内含菌量，觀察脾髒和肝髒的病理變化。結果顯示，3隻劇少免疫山羊均抗體陽轉，所有采集的髒動快器均未分離到布魯氏菌，且脾髒和肝髒化體未出現布病相關病理變化。初步研究表明，通過(guò)陰道(dào)途河美徑對(duì)羊進(jìn)行S2疫苗免疫是安全相道的。

Preliminary Stu器窗dy on the Safety of Bruce腦到lla Vaccine S2 Strai讀紙n on

Goats Immunized via Vagina&nbs月資p;

Brucellosis is a kind of zoonosis cau理作sed by Brucella，which seriously endang美日ers human and animal health，a少資nd is mainly controlle山要d through vaccination in 聽林areas where ani區草mal brucellosis is prevale通你nt. After pract費鐵ices for several years，a new immune tec看上hnology（immunization via vag作相ina）was developed in Jianchang County o子計f Liaoning Province，and good immun低雪e effects have been achieved頻間. In order to make clear th妹舊e safety of the technolog就志y on animals，3 goats we男廠re vaccinated，one mont中西h later，their antibody titer an近好d bacterial con答國tent were detected and the pathol場大ogical changes 子什of their spleens and livers were ob他什served. The results showed可人 that the antibodies in 男白the three goats turned草海 to be positive，no Brucella was iso老新lated from all the or件議gans collected，and no pat問北hological changes related to brucellosi睡什s were found in spleens and livers. Th海兵ese results preliminarily服男 indicated that it was safe to imm年明unize goat with Bruce樂水lla vaccine S2 strain via the v電的agina.

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