碳納米管具有多種(zhǒng)良好(hǎo)的生物學(xué)特性，是近幾年志黃科研工作者研究的熱點納米材料之一，可增強機體問西免疫應答，提高特異性抗體水平，在免疫佐劑研發(fā)領域內音展現了良好(hǎo)的應用前景。碳納米管作爲免疫佐劑的優勢在于其有極高湖頻的比表面(miàn)積，可以非特異性吸附多種(場票zhǒng)藥物、基因、蛋白質等物朋農質；可進(jìn)入免疫細胞，且不破壞細胞膜結構，從做好而爲抗原運輸和遞送提供了有利條件。目前關于碳納米管去筆作用機體免疫應答的研究取得了一定進(j哥還ìn)展，但其增強機體免疫應答的确切作用機制尚未揭示，今後(hòu)需對(美習duì)碳納米管最佳的功能(néng)黃術化修飾方式、最适的免疫劑量及免疫毒性三方面(miàn)進(jìn)行通機深入研究。本文總結分析了碳納米管作爲媽錢佐劑的優勢及其應用研究情況，以及存在的潛在問題及下一樂有步研究重點，以期爲碳納米管免疫佐劑的研發(fā)提供新思路。文的

Research Progress on 明森the Carbon Nanotube 這懂as a Novel Immune Adjuvant

With excellent biological properties站來，carbon nanotube（CNT）has be看黑come one of the ke年能y nano materials studied by sc唱刀ience researchers in recent yea子又rs，which could improve immune間還 response and increase the level of spe大鐘cific antibodies，with a good applicatio人近n prospect in the development of i雪遠mmune adjuvant. With extremely high s鐵市pecific surface area，CNT，as an i能生mmune adjuvant，could non-speci對微fically absorb vari公長ous drugs，genes，proteins 日筆and other substances，and enter immune c廠煙ells without damaging any structu快東re of cell membrane吃很 for the purpose of provid遠唱ing favorable conditions to 的件transport and deliver antigens. At pre畫農sent，the studies on the effect 我行of CNT on immune 場內response have taken a step f著謝orward，but the exact mechanism for 上刀enhancing immune response has no輛木t been identifie暗農d. Therefore，the optimal fu這輛nctionalization，immu化事ne dose and immunotoxicity of 下身carbon nanotubes should b照草e further studied in the futur習長e. In the paper，the advantages關雪 and application of CNT as an adju低做vant，as well as possible problem鄉林s and future research focus wer書綠e analyzed with a view to providing公慢 some new ideas for next s腦得tep.

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