RIG-I樣(yàng)受體（RLRs）是細胞質中重要的模式識别受體（PRRs草短），LGP2是其重要的家族成(chéng)員之雜件一。LGP2在抗病毒天然免疫應答中上冷具有特殊功能(néng)，能(néng錯哥)夠雙向(xiàng)調控RIG-I、MDA5介導的I型幹擾素（作為IFNs）信号通路。在不同病毒感樂木染宿主的過(guò)程中，LG司可P2也表現出明顯的功能(néng)差異。在雙鏈藍生DNA病毒中，LGP2在RIG-I介導的信号傳導過(guò)程中起(qǐ)志明正向(xiàng)調節作用；在單鏈DNA病毒見空中，LGP2能(néng)夠促進(市要jìn)CARDs區失活的RIG-I與非典型泛素鏈結合，從而誘導I型IFNs産哥但生；在雙鏈RNA病毒中，正常表達可增強RIG-你算I、MDA5對(duì)dsRNA的識别能(nén商可g)力；在正義單鏈RNA病毒中，LGP2參與對(duì)正義單鏈來腦RNA病毒的識别過(guò)程；行舞在負義單鏈RNA病毒中，LGP2有時(sh好房í)可作爲IFNs的誘導劑。另外，LGP2在請亮适應性免疫應答中也發(fā)揮開市著(zhe)重要作用，能(néng)夠通過(guò)農志不同途徑調控T細胞存活與凋亡。目前在放湖調控RIG-I、MDA5介導的信号通路與抗病毒免疫應答中，尚不清楚LGP2發(著輛fā)揮的确切功能(néng)和其作用機制，未來可進(jìn)湖現一步加深LGP2在細胞免疫應答中的作用及機制研紅音究。本文就(jiù)近年來LGP2在R來窗LRs介導的信号通路和抗病毒免劇愛疫應答中發(fā)揮的作用作綜述，以期爲LGP2的進(jìn)一步研究和機費弟體抵禦病毒感染新機制提供參考。
Studies on the 村歌Roles of Innate Immune RIG-I-like 吃樂Receptor LGP2 in Antiviral Immunity
RIG-I-like receptor媽地s（RLRs）are the 玩我key pattern recognition recep道河tors（PRRs）in cytoplasm，and L窗錢GP2 is one of its importan資錯t family member會音s. LGP2 functions specially in anti舊作viral innate immune response，and could 時冷regulate the type-I interferon（學到IFNs）signaling mediated by RIG-I a服些nd MDA5 bidirectional開這. Functional differences are also 知放obviously present in LGP2 during th用從e process of infection 事友with different viruses in hosts.LGP2 拍不positively regulates the去舞 progress of sign到遠aling mediated by RIG-I in doub友廠le-stranded DNA（dsDNA）viruses，induces 行信type-I IFNs through su師雨pporting the binding of購員 inactivated RIG-I located i聽她n CARDs region with atyp火報ical ubiquitin ch謝了ainin single-strande你通d DNA（ssDNA）viruses，increases the cap雨錯acity of RIG-I and MDA5 to rec微海ognize dsRNA through normal exp火大ression in double樂們-stranded RNA（dsR費低NA）viruses，participates in the 嗎好process of recognition for positive作冷-sense single-s是雪tranded RNA（+ssRNA）viruses，and 坐紅is sometimes used as 作畫an inducer for IFNs in nega能靜tive-sense single-stranded RNA（知在-ssRNA）viruses. In ad機有dition，LGP2 also plays 會雜an important role i拍會n adaptive immune response，regulat外的ing the survival 女金and apoptosis of T cells through di什農fferent ways. Currently，its spec得海ific functions and mechanisms for廠文 regulation of 上技signaling mediated 老銀by RIG-I and MDA5 and for antiviral 錢光immune response are still unclear，身動which should be further studied呢算 in the future. In the pape兒刀r，the studies on the roles低河 of LGP2 in signaling mediated by RL訊輛Rs and antiviral見員 immune response in北雪 recent years were revi秒黑ewed，with a view to providing a refe說他rence for further study 暗懂on LGP2 and new mechanisms of答短 resistance to vi她在ral infection.
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