豬流行性腹瀉（PED）是由豬流行性腹瀉病毒（PEDV這朋）引起(qǐ)的，以腹瀉爲主要症狀的急性腸道(dào唱林)傳染病，是長(cháng)期以現朋來危害我國(guó)養豬業健康發(fā)展的常見疾病之一。PEDV通過(g為關uò)基因插入、缺失和重組等方式不斷發(fā)我嗎生演化和變異，高緻病力毒株、變異毒株不行你斷出現，各類毒株之間的抗原性存在明顯差異，導緻臨床上豬腹瀉情況更加複雜。自外慢2010年10月以來，由PEDV變異株引起(qǐ)的PED在我國(guó)大爸務規模暴發(fā)流行，用經(jīng)車下典毒株制備疫苗的免疫效果并不理想，因而造成(chéng)重大經(jīn很去g)濟損失。本文綜述了PEDV在我國(guó)和開的流行現狀及分子遺傳演化特征，旨在爲PED疫苗和診斷試劑研發(fā)提供參考。低到

Prevalence and Mole綠體cular Genetic Evolution of Porcin舞能e Epidemic Diarrhea話笑 Virus in China

Porcine epidemic diarrhea（PED）is an 內錢acute intestinal infecti都員ous disease caused by porcine epidem但筆ic diarrhea virus（PEDV）with 長鄉main symptom of diarr坐數hea，and is listed as男資 one of common diseases endan門業gering healthy developm生靜ent of China's pig industry for a l開學ong time. As PEDV h中照as been continuously evolving and 鐵紙mutating through gene inserti在好on，deletion and recombina術理tion，highly pathogen東紅ic and mutated 是多strains are continuously appearing，and 鐵跳the antigenicity among va鐘報rious strains is o銀見bviously different，leading們有 to the more complicated status of上習 diarrhea in practice. Since October 2花弟010，the outbreak of PED caused by var光公iant strain of PEDV件窗 has widely occurred in China分厭，which has caused huge eco市件nomic losses as the vacci水資ne prepared with the classical stra中樹in failed to effectively work. In th國做e paper，the preva開學lence and molecular gene業亮tic evolution of PEDV in China 可場were reviewed，aiming to她也 provide a reference for future rese用冷arch and develop服開ment of vaccines and dia放習gnostic reagents against the virus.計光

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