禽星狀病毒研究進(jìn)展

2022-06-07 12:28:14 張富友,鄧春冉,王素春,等 2022年第5期《中國(guó)動物檢疫》

禽星狀病毒(avian astrovirus,從廠AAstV)屬于星狀病毒科,包含多種(zhǒng)亞型們高,可以引發(fā)禽腎炎、鴨肝炎以及現火火雞腹瀉等多種(zhǒng)疾病,禽類感染後(hòu)表現生暗員長(cháng)發(fā)育遲緩、産蛋下還線降,嚴重時(shí)可導緻死亡,給養殖業時化造成(chéng)一定的損失。此外,AAstV具有感染人的潛在風險。著件目前AAstV的緻病機理暫不清楚,隻有火雞星狀病毒引發(fā)腸炎的頻用緻病機制可作爲參考。許多方法已用于AAstV檢測,如電鏡檢測、酶聯免疫少化吸附試驗、細胞培養和病毒分離以及分子技術檢測等。AAstV亞型較多,嗎你疫苗和藥物研發(fā)存在較大難新兵度,給該病防治帶來一定的挑戰。本文圍繞AAstV的病原學(xué子畫)、國(guó)内外流行情況、感染後(hòu)臨床症狀及緻病機制事事以及檢測方法和控制措施等進(jìn)行了綜述,以期爲後秒草(hòu)期進(jìn)一步研究提供參考。

Advances in the Researches on Avian A兵大strovirus

Avian astrovirus術有(AAstV),a member of astroviridae famil做男y,includes a variety of 物綠subtypes,which may lead to 短金avian nephritis,du月事ck hepatitis,turkey diarrhea an西綠d other diseases. Such symptoms as 音木growth retardation and decline in木秒 egg production事他 even death may be observed 畫分in infected poultry,which wo要吃uld bring certain losses to街錢 breeding industry. In ad門長dition,the virus may bring poten裡腦tial risk to human. Howeve習電r,its pathogenic mechanism has b下森een unknown,except聽喝 the one for enteritis 要工caused by Turkey astrovir司對us that may be used as a refe城金rence. The virus ma動妹y be detected by many methods,suc唱火h as electron microscopy,enzyme-街請linked immunosorbent assay(ELISA),cell我畫 culture and virus isolatio議林n,molecular tec玩通hnology,etc. However,it would b她醫e difficult to develop vaccines or dr上區ugs due to many 笑愛subtypes,which bri雜書ngs certain challenges to the短了 prevention and treatment木湖 of the disease. In the paper,the etio黑土logy,epidemic statu吧麗s all over the world,clinical symptoms,務制pathogenic mech電子anism,detection meth身紙ods and countermeasures were唱就 summarized,so as to provid土你e a reference for間海 further researches in the futur亮離e.

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